Trimethyl phosphite → HCID 21612902, compound

HRID 1682281Notes

Reaction equation

HRID 1682281 reaction equation
[CH2:1]([O:3][C:4](=[O:14])[CH:5]([NH:11][CH:12]=[O:13])[CH:6](O)[C:7]([CH3:9])=[CH2:8])[CH3:2].S(Br)(Br)=O.[P:19]([O:24]C)([O:22][CH3:23])[O:20][CH3:21]>>[CH2:1]([O:3][C:4](=[O:14])[CH:5]([NH:11][CH:12]=[O:13])/[CH:6]=[C:7](\[CH3:9])/[CH2:8][P:19]([O:22][CH3:23])([O:20][CH3:21])=[O:24])[CH3:2]

Participants

4

Reactant 3

HCID 8472Trimethyl phosphiteHCID 68176Thionyl bromideHCID 14332470HCID 14332470, compound

Product 1

HCID 21612902HCID 21612902, compound

Procedure

By reaction of 2-formylamino-3-hydroxy-4-methyl-4-pentenoic acid ethyl ester with thionyl bromide and subsequent treatment with trimethyl phosphite in a manner analogous to that described in Example 1, E-2-formylamino-4-methyl-5-dimethylphosphono-3-pentenoic acid ethyl ester is obtained in the form of a pale yellow oil.

Sources & evidence

ORD record
ord-b8ccd28f7c384826ab5d455d2fb43761
Source dataset
uspto-grants-1992_12
Patent number
US05175344

Reaction notes

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