反应详情

2-Chlorobenzothiazole (5 g) is heated in ethanol (75 ml) with piperazine (3.05 g) for 20 h. The mixture is partitioned between methylene chloride/ether and aqueous sodium bicarbonate. The organic phase is separated, dried with sodium sulfate and concentrated to give the title compound.

1. customThe mixture is partitioned between methylene chloride/ether and aqueous sodium bicarbonate
2. customThe organic phase is separated
3. dry with materialdried with sodium sulfate
4. concentrationconcentrated