2-Chloropropionic acid → N-Benzoyl-2-methyl-3-oxomorpholine

HRID 1682376Notes

Reaction equation

HRID 1682376 reaction equation
[C:1]([N:9]1[CH2:14][CH2:13][O:12][CH2:11][C:10]1=[O:15])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl[CH:17](C)C(O)=O>>[C:1]([N:9]1[CH2:14][CH2:13][O:12][CH:11]([CH3:17])[C:10]1=[O:15])(=[O:8])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 117342-Chloropropionic acidHCID 122940964-Benzoylmorpholin-3-one

Product 1

HCID 19043814N-Benzoyl-2-methyl-3-oxomorpholine

Procedure

Synthesized as for N-benzoyl-3-oxomorpholine (Example I) using 2-chloropropionic acid (Aldrich) in place of chloroacetic acid.

Sources & evidence

ORD record
ord-195a521aa5224ded91009fa3a418ecee
Source dataset
uspto-grants-1997_06
Patent number
US05635103

Reaction notes

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