Sodium hydride → HCID 18694775, compound

HRID 1682423Notes

Reaction equation

HRID 1682423 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:9]=[CH:10][NH:11][CH:12]=2)=[CH:4][CH:3]=1.[H-].[Na+].Br[CH2:16][CH2:17][CH2:18][CH2:19][NH:20]C(=O)C1C(=CC=CC=1)C(N)=O>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[N:9]=[CH:10][N:11]([CH2:16][CH2:17][CH2:18][CH2:19][NH2:20])[CH:12]=2)=[CH:6][CH:7]=1

Participants

4

Reactant 3

HCID 24758Sodium hydrideHCID 18694800HCID 18694800, compoundHCID 178418867HCID 178418867, compound

Product 1

HCID 18694775HCID 18694775, compoundYield 81.8%

Procedure

Using the procedure of Stage A of Example 1, 10 g of the product of Stage A, 1.95 g of sodium hydride and 11.80 g of N-4-bromobutyl-phthalamide were reacted to obtain 7.53 g of the expected product melting at 138°-140° C.

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-1a3ebcd1eb7e4b4b861c4e9369d8b2cd
Source dataset
uspto-grants-1997_06
Patent number
US05635485

Reaction notes

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