Hydrazine hydrate (1:1) → HCID 18694778, compound

HRID 1682424Notes

Reaction equation

HRID 1682424 reaction equation
[CH3:1][O:2][C:3]1[CH:12]=[C:11]2[C:6]([C:7]([CH2:13][CH2:14][CH2:15][CH2:16][N:17]3C(=O)C4C(=CC=CC=4)C3=O)=[CH:8][CH:9]=[N:10]2)=[CH:5][CH:4]=1.O.NN>C(O)C>[CH3:1][O:2][C:3]1[CH:12]=[C:11]2[C:6]([C:7]([CH2:13][CH2:14][CH2:15][CH2:16][NH2:17])=[CH:8][CH:9]=[N:10]2)=[CH:5][CH:4]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 18694774HCID 18694774, compound

Product 1

HCID 18694778HCID 18694778, compoundYield 99.1%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

3.46 g of the product of Stage C were dissolved in 70 ml of hot ethanol and 1.86 ml of hydrazine hydrate were added. The reaction medium was refluxed for 17 hours and the precipitate was eliminated by filtration. The solvent was evaporated and the residue was taken up in 70 ml of dichloromethane. Filtration was carried out and the solvent was evaporated to obtain 2.19 g of the expected product.

Workup

  1. temperatureThe reaction medium was refluxed for 17 hours
  2. filtrationthe precipitate was eliminated by filtration
  3. customThe solvent was evaporated
  4. filtrationFiltration
  5. customthe solvent was evaporated

Sources & evidence

ORD record
ord-37ae7052b6764931860b54b47774f3f0
Source dataset
uspto-grants-1997_06
Patent number
US05635485

Reaction notes

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