Benzene → 2-[2-(4-Methoxycarbonylmethylphenoxy)-1-methylethyl]-amino-1-(2-naphthyl)ethanol

HRID 1682699ノート

反応式

HRID 1682699 の反応式
N[CH2:2][CH:3]([C:5]1[CH:14]=[CH:13][C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[CH:6]=1)[OH:4].O=[C:16]([CH3:30])[CH2:17][O:18][C:19]1[CH:24]=[CH:23][C:22]([CH2:25][C:26]([O:28][CH3:29])=[O:27])=[CH:21][CH:20]=1.C1C=CC=CC=1.C([BH3-])#[N:38].[Na+]>CO>[CH3:29][O:28][C:26]([CH2:25][C:22]1[CH:23]=[CH:24][C:19]([O:18][CH2:17][CH:16]([CH2:2][C:3]([NH2:38])([C:5]2[CH:14]=[CH:13][C:12]3[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=3)[CH:6]=2)[OH:4])[CH3:30])=[CH:20][CH:21]=1)=[O:27]

参加物

6

反応物 4

HCID 241BenzeneHCID 27353792-Amino-1-(naphthalen-2-yl)ethan-1-olHCID 5003444Sodium cyanoborohydrideHCID 21832178Methyl 4-(2-oxopropoxy)phenylacetate

生成物 1

HCID 218321742-[2-(4-Methoxycarbonylmethylphenoxy)-1-methylethyl]-amino-1-(2-naphthyl)ethanol収率 51.2%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

Following a procedure similar to that described in Example 6, but using 3 g of 2-amino-1-(2-naphthyl)ethanol (prepared as described in Preparation 9), 3.87 g of methyl 4-(2-oxopropoxy)phenylacetate (prepared as described in Preparation 3), 60 ml of benzene, 50 ml of absolute methanol and 2.49 g of sodium cyanoborohydride, 3.23 g of the title compound were obtained having an Rf=0.15 (thin layer chromatography over silica gel, using ethyl acetate as the developing solvent).

出典と根拠

ORDレコード
ord-522f2672ba624dfb9bf9c9b4bad3b884
出典データセット
uspto-grants-1997_06
特許番号
US05635534

反応ノート

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