反应详情

30 ml of hexane were slowly added to a solution of 1.6 g of 2-[2-(4-methoxycarbonylmethylphenoxy)-1(R)methylethyl]amino-1(R)-(3-chlorophenyl)ethanol (prepared as described in Example 46) and 491 mg of fumaric acid in 5 ml of ethyl acetate, whilst irradiating the reaction mixture with ultrasonic waves. The crystals which precipitated were collected by filtration and dried, to give 1.95 g of the title compound as crystals, melting at 73°-78° C. [α]D23 -19.4° (c=1.01, methanol).

1. customwhilst irradiating the reaction mixture with ultrasonic waves
2. customThe crystals which precipitated
3. filtrationwere collected by filtration
4. customdried