Hydrochloric Acid → HCID 67559449, compound

HRID 1682994Notes

Reaction equation

HRID 1682994 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][C:11]([C:24]#[N:25])([C:14]2[CH:23]=[CH:22][C:21]3[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=3)[CH:15]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:26].O1CCOCC1>>[ClH:26].[C:24]([C:11]1([C:14]2[CH:23]=[CH:22][C:21]3[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=3)[CH:15]=2)[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]1)#[N:25]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 49760261tert-Butyl 4-cyano-4-(naphthalen-2-yl)piperidine-1-carboxylate

Product 1

HCID 67559449HCID 67559449, compound

Procedure

Combine 1-tert-butoxycarbonyl-4-cyano-4-(naphth-2-yl)-piperidine (3.12 mmol) and HCl in dioxane (10 mL, 40 mmol, 4N, 13 eq.) at ambient temperature for 1 h. Concentrate the solvent in vacuo and dry under high vacuum to give the title compound.

Workup

  1. concentrationConcentrate the solvent in vacuo
  2. customdry under high vacuum

Sources & evidence

ORD record
ord-9272606a1ff940b59d09c3d62c202009
Source dataset
uspto-grants-1997_06
Patent number
US05635510

Reaction notes

Loading…