2-(Pyridin-4-yl)acetonitrile → 1-Boc-4-cyano-4-(4-pyridinyl)-piperidine

HRID 1682997Notes

Reaction equation

HRID 1682997 reaction equation
[N:1]1[CH:6]=[CH:5][C:4]([CH2:7][C:8]#[N:9])=[CH:3][CH:2]=1.Cl[CH2:11][CH2:12][N:13]([CH2:21][CH2:22]Cl)[C:14]([O:16][C:17]([CH3:20])([CH3:19])[CH3:18])=[O:15]>>[C:17]([O:16][C:14]([N:13]1[CH2:21][CH2:22][C:7]([C:8]#[N:9])([C:4]2[CH:5]=[CH:6][N:1]=[CH:2][CH:3]=2)[CH2:11][CH2:12]1)=[O:15])([CH3:20])([CH3:19])[CH3:18]

Participants

3

Reactant 2

HCID 41120852-(Pyridin-4-yl)acetonitrileHCID 11230235N-BOC-N,N-Bis(2-chloroethyl)amine

Product 1

HCID 539443251-Boc-4-cyano-4-(4-pyridinyl)-piperidine

Procedure

Prepare by the method of example 30.2 using 4-pyridylacetonitrile (10 mmol) and 2-chloro-N-(2-chloroethyl)-N-tert-butoxycarbonyl-ethanamine (11 mmol). Purify to give the title compound.

Workup

  1. customPurify

Sources & evidence

ORD record
ord-3c6bfe251550441f9c604d34b3b642db
Source dataset
uspto-grants-1997_06
Patent number
US05635510

Reaction notes

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