3-Pyridineacetonitrile → tert-Butyl 4-cyano-4-(pyridin-3-yl)piperidine-1-carboxylate

HRID 1683002Notes

Reaction equation

[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([CH2:7][C:8]#[N:9])[CH:2]=1.Cl[CH2:11][CH2:12][N:13]([CH2:21][CH2:22]Cl)[C:14]([O:16][C:17]([CH3:20])([CH3:19])[CH3:18])=[O:15]>>[C:17]([O:16][C:14]([N:13]1[CH2:21][CH2:22][C:7]([C:8]#[N:9])([C:3]2[CH:2]=[N:1][CH:6]=[CH:5][CH:4]=2)[CH2:11][CH2:12]1)=[O:15])([CH3:20])([CH3:19])[CH3:18]

Participants

Reactant 2

HCID 809233-Pyridineacetonitrile

HCID 11230235N-BOC-N,N-Bis(2-chloroethyl)amine

Product 1

HCID 53793625tert-Butyl 4-cyano-4-(pyridin-3-yl)piperidine-1-carboxylate

Procedure

Prepare by the method of example 30.2 using 3-pyridylacetonitrile (10 mmol) and 2-chloro-N-(2-chloroethyl)-N-tert-butoxycarbonyl-ethanamine (11 mmol).

Sources & evidence

ORD record: ord-4f2b25ac94824791a82b8635a8f96cde
Source dataset: uspto-grants-1997_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05635510

Reaction notes

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