Hydrochloric Acid → 4-(Pyridin-3-yl)-piperidine-4-carboxylic acid amide hydrochloride

HRID 1683005Notes

Reaction equation

C(OC([N:8]1[CH2:13][CH2:12][C:11]([C:17]2[CH:18]=[N:19][CH:20]=[CH:21][CH:22]=2)([C:14]([NH2:16])=[O:15])[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:23].O1CCOCC1>>[ClH:23].[N:19]1[CH:20]=[CH:21][CH:22]=[C:17]([C:11]2([C:14]([NH2:16])=[O:15])[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]2)[CH:18]=1

Participants

Reactant 3

HCID 313Hydrochloric Acid

HCID 312751,4-Dioxane

HCID 539785191-Tert-butoxycarbonyl-4-(pyridin-3-yl)-piperidine-4-carboxylic acid amide

Product 1

HCID 675594834-(Pyridin-3-yl)-piperidine-4-carboxylic acid amide hydrochloride

Procedure

Prepare by the method of example 20.10 using 1-tert-butoxycarbonyl-4-(pyridin-3-yl)-piperidine-4-carboxylic acid amide (3 mmol) and HCl in dioxane (40 mmol, 4N) to give the title compound.

Sources & evidence

ORD record: ord-539b926270e24b82b7c94f6835821a73
Source dataset: uspto-grants-1997_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05635510

Reaction notes

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