Hydrochloric Acid → 4-(Pyridin-2-yl)-piperidine-4-carboxylic acid amide hydrochloride

HRID 1683010Notes

Reaction equation

C(OC([N:8]1[CH2:13][CH2:12][C:11]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][N:18]=2)([C:14]([NH2:16])=[O:15])[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:23].O1CCOCC1>>[ClH:23].[N:18]1[CH:19]=[CH:20][CH:21]=[CH:22][C:17]=1[C:11]1([C:14]([NH2:16])=[O:15])[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]1

Participants

Reactant 3

HCID 313Hydrochloric Acid

HCID 312751,4-Dioxane

HCID 542754451-Tert-butoxycarbonyl-4-(pyridin-2-yl)-piperidine-4-carboxylic acid amide

Product 1

HCID 675613744-(Pyridin-2-yl)-piperidine-4-carboxylic acid amide hydrochloride

Procedure

Prepare by the method of example 20.10 using 1-tert-butoxycarbonyl-4-(pyridin-2-yl)-piperidine-4-carboxylic acid amide (3 mmol) and HCl in dioxane (40 mmol, 4N) to give the title compound.

Sources & evidence

ORD record: ord-8b02b15bdf754d86a2453a7b6e9a3976
Source dataset: uspto-grants-1997_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05635510

Reaction notes

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