1-(4-Tert-butylphenyl)-2-chloroethan-1-one → 2-[3-(3,4-Dichloro-phenyl)-1-(4-tert-butyl-phenacyl)-pyrrolidin-3-yl]-ethanol

HRID 1683027Notes

Reaction equation

HRID 1683027 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2([CH2:14][CH2:15][OH:16])[CH2:13][CH2:12][NH:11][CH2:10]2)[CH:5]=[CH:6][C:7]=1[Cl:8].[C:17]([C:21]1[CH:30]=[CH:29][C:24]([C:25](=[O:28])[CH2:26]Cl)=[CH:23][CH:22]=1)([CH3:20])([CH3:19])[CH3:18]>>[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2([CH2:14][CH2:15][OH:16])[CH2:13][CH2:12][N:11]([CH2:26][C:25]([C:24]3[CH:29]=[CH:30][C:21]([C:17]([CH3:20])([CH3:19])[CH3:18])=[CH:22][CH:23]=3)=[O:28])[CH2:10]2)[CH:5]=[CH:6][C:7]=1[Cl:8]

Participants

3

Reactant 2

HCID 2296611-(4-Tert-butylphenyl)-2-chloroethan-1-oneHCID 184644272-(3-(3,4-Dichlorophenyl)pyrrolidin-3-yl)ethanol

Product 1

HCID 540167032-[3-(3,4-Dichloro-phenyl)-1-(4-tert-butyl-phenacyl)-pyrrolidin-3-yl]-ethanol

Procedure

Prepare by the method of example 3.1 using 2-[3-(3,4-dichloro-phenyl)-pyrrolidin-3-yl]-ethanol (2 mmol) and 4-tert-butyl-phenacyl chloride (2 mmol). Chromatograph on silica gel to give the title compound.

Sources & evidence

ORD record
ord-21b0d107a7b84751a45047e1342ce93e
Source dataset
uspto-grants-1997_06
Patent number
US05635510

Reaction notes

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