反应详情

Combine 3-hydroxy-phenyl acetic acid (9.26 g, 60.9 mmol), isopropyl iodide (42.6 g, 250 mmol), and acetone (80 mL). Add portionwise, potassium carbonate (16.9 g, 122 mmol). Heat to reflux with vigorous mechanical stirring. After 20 hours, cool to ambient temperature and evaporate in vacuo to give a residue. Partition the residue between diethyl ether and 5% sodium hydroxide solution. Extract the organic layer with water and a saturated sodium chloride solution. Dry the organic layer over MgSO4, filter and evaporate in vacuo to obtain a liquid. Bulb-to-bulb distillation gives 3-isopropoxy-phenyl-acetic acid isopropyl ester: bp; 125° C. at 0.2 mm of Hg.

1. additionAdd portionwise
2. temperatureHeat
3. temperatureto reflux with vigorous mechanical stirring
4. customevaporate in vacuo
5. customto give a residue
6. customPartition the residue between diethyl ether and 5% sodium hydroxide solution
7. extractionExtract the organic layer with water
8. dry with materialDry the organic layer over MgSO4
9. filtrationfilter
10. customevaporate in vacuo
11. customto obtain a liquid
12. distillationBulb-to-bulb distillation