2-(3-(3,4-Dichlorophenyl)pyrrolidin-3-yl)ethanol → 2-[3-(3,4-Dichloro-phenyl)-1-(3-isopropoxy-phenacyl)-pyrrolidin-3-yl]-ethanol

HRID 1683032Notes

Reaction equation

HRID 1683032 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2([CH2:14][CH2:15][OH:16])[CH2:13][CH2:12][NH:11][CH2:10]2)[CH:5]=[CH:6][C:7]=1[Cl:8].[CH:17]([O:20][C:21]1[CH:22]=[C:23]([CH:28]=[CH:29][CH:30]=1)[C:24](=[O:27])[CH2:25]Cl)([CH3:19])[CH3:18]>>[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2([CH2:14][CH2:15][OH:16])[CH2:13][CH2:12][N:11]([CH2:25][C:24]([C:23]3[CH:28]=[CH:29][CH:30]=[C:21]([O:20][CH:17]([CH3:19])[CH3:18])[CH:22]=3)=[O:27])[CH2:10]2)[CH:5]=[CH:6][C:7]=1[Cl:8]

Participants

3

Reactant 2

HCID 184644272-(3-(3,4-Dichlorophenyl)pyrrolidin-3-yl)ethanolHCID 540760232-Chloro-1-[3-(1-methylethoxy)phenyl]ethanone

Product 1

HCID 541410672-[3-(3,4-Dichloro-phenyl)-1-(3-isopropoxy-phenacyl)-pyrrolidin-3-yl]-ethanol

Procedure

Prepare by the method of example 3.1 using 2-[3-(3,4-dichloro-phenyl)-pyrrolidin-3-yl]-ethanol (2 mmol) and 3-isopropoxy-phenacyl chloride (2 mmol). Chromatograph on silica gel to give the title compound. Rf =0.44 (silica gel, 5% methanol/dichloromethane).

Sources & evidence

ORD record
ord-134b0c25d58a4b0381de52e7aef41709
Source dataset
uspto-grants-1997_06
Patent number
US05635510

Reaction notes

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