反应详情

温度

50 °C

Combine 1-benzyl-4-oxo-piperidine (100 mmol), 4-fluorophenylamine (110 mmol), and toluene (300 mL). Heat at reflux for 3 h with azeotropic removal of water. Cool to 50° C. Add acetone cyanohydrin (277 mmol). Slowly distill away the acetone. Concentrate the solvent in vacuo to obtain a residue. Chromatograph on silica gel to obtain the title compound.

1. temperatureHeat
2. distillationSlowly distill away the acetone
3. concentrationConcentrate the solvent in vacuo
4. customto obtain a residue