HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1683041Generated: November 1, 2026
Toluene → 1-Benzyl-4-((4-fluorophenyl)amino)piperidine-4-carbonitrile
https://huagongshe.com/reaction/1683041
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Toluene | HCID 1140 | — |
| Reactant | Acetone Cyanohydrin | HCID 6406 | — |
| Reactant | 4-Fluoroaniline | HCID 9731 | — |
| Reactant | 1-Benzyl-4-piperidone | HCID 19220 | — |
| Solvent | Water | HCID 962 | — |
| Product | 1-Benzyl-4-((4-fluorophenyl)amino)piperidine-4-carbonitrile | HCID 3017222 | — |
Reaction Steps
Combine 1-benzyl-4-oxo-piperidine (100 mmol), 4-fluorophenylamine (110 mmol), and toluene (300 mL). Heat at reflux for 3 h with azeotropic removal of water. Cool to 50° C. Add acetone cyanohydrin (277 mmol). Slowly distill away the acetone. Concentrate the solvent in vacuo to obtain a residue. Chromatograph on silica gel to obtain the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05635510 |
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| Source dataset | uspto-grants-1997_06 |
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| ORD ID | ord-4b92566e4866453db8ef99d28d7d168c |
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| Source note | uspto-grants-1997_06 |
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