反应详情

Cautiously combine 1-benzyl-4-(4-fluoro-phenylamino)-piperidine-4-carbonitrile (60 mmol) and concentrated sulfuric acid (270 mL). Let stand for 24 h at ambient temperature. Cautiously pour the reaction mixture into excess dilute ammonium hydroxide solution/ice. Extract with dichloromethane (3×300 mL). Combine the dichloromethane extracts and extract them using saturated NaHCO3 solution (3×300 mL). Dry the dichloromethane solution over magnesium sulfate, filter, and concentrate in vacuo to obtain a residue. Purify to obtain the title compound.

1. extractionExtract with dichloromethane (3×300 mL)
2. extractionCombine the dichloromethane extracts and extract them
3. dry with materialDry the dichloromethane solution over magnesium sulfate
4. filtrationfilter
5. concentrationconcentrate in vacuo
6. customto obtain a residue
7. customPurify