Dimethylformamide dimethyl acetal → HCID 45789390, compound

HRID 1683043Notes

Reaction equation

HRID 1683043 reaction equation
[CH2:1]([N:8]1[CH2:13][CH2:12][C:11]([NH:17][C:18]2[CH:23]=[CH:22][C:21]([F:24])=[CH:20][CH:19]=2)([C:14]([NH2:16])=[O:15])[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:25]OC(OC)N(C)C>C1(C)C=CC=CC=1>[CH2:1]([N:8]1[CH2:13][CH2:12][C:11]2([N:17]([C:18]3[CH:19]=[CH:20][C:21]([F:24])=[CH:22][CH:23]=3)[CH:25]=[N:16][C:14]2=[O:15])[CH2:10][CH2:9]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 78373Dimethylformamide dimethyl acetalHCID 30172231-Benzyl-4-((4-fluorophenyl)amino)piperidine-4-carboxamide

Product 1

HCID 45789390HCID 45789390, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

Mix 1-benzyl-4-(4-fluoro-phenylamino)-piperidine-4-carboxylic acid amide (20 mmol) and hot toluene (240 mL). Add dimethoxy-N,N-dimethylmethanamine (20 mL) and heat at reflux for 48 h. Concentrate in vacuo to obtain a residue. Purify to obtain the title compound.

Workup

  1. temperatureat reflux for 48 h
  2. concentrationConcentrate in vacuo
  3. customto obtain a residue
  4. customPurify

Sources & evidence

ORD record
ord-dde6651e06d6468ebf25b86ea06d0918
Source dataset
uspto-grants-1997_06
Patent number
US05635510

Reaction notes

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