Trifluoroacetic acid → HCID 12834319, compound

HRID 1683048Notes

Reaction equation

HRID 1683048 reaction equation
FC(F)(F)C(O)=O.C(OC([N:15]1[CH2:39][CH2:38][C:18]2([N:22]([C:23]3[CH:28]=[CH:27][C:26]([F:29])=[CH:25][CH:24]=3)[CH2:21][N:20]([CH2:30][C:31]3[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=3)[C:19]2=[O:37])[CH2:17][CH2:16]1)=O)(C)(C)C>C(OCC)C>[CH2:30]([N:20]1[C:19](=[O:37])[C:18]2([CH2:38][CH2:39][NH:15][CH2:16][CH2:17]2)[N:22]([C:23]2[CH:28]=[CH:27][C:26]([F:29])=[CH:25][CH:24]=2)[CH2:21]1)[C:31]1[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 541984368-Tert-butoxycarbonyl-3-benzyl-1-(4-fluoro-phenyl)-4-oxo-1,3,8-triaza-spiro[4.5]decane

Product 1

HCID 12834319HCID 12834319, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

Cool trifluoroacetic acid (20 mL) using an ice bath and add 8-tert-butoxycarbonyl-3-benzyl-1-(4-fluoro-phenyl)-4-oxo-1,3,8-triaza-spiro[4.5]decane (10 mmol). After 1 h, dilute with diethyl ether (150 mL), filter to obtain a residue. Purify to obtain the title compound.

Workup

  1. filtrationfilter
  2. customto obtain a residue
  3. customPurify

Sources & evidence

ORD record
ord-bbce075b1cc3416195e53d896d857969
Source dataset
uspto-grants-1997_06
Patent number
US05635510

Reaction notes

Loading…