Oxalyl chloride → 3-Isopropoxybenzoyl chloride

HRID 1683074Notes

Reaction equation

HRID 1683074 reaction equation
[CH:1]([O:4][C:5]1[CH:6]=[C:7]([CH:11]=[CH:12][CH:13]=1)[C:8](O)=[O:9])([CH3:3])[CH3:2].C(Cl)(=O)C([Cl:17])=O>ClCCl>[CH:1]([O:4][C:5]1[CH:6]=[C:7]([CH:11]=[CH:12][CH:13]=1)[C:8]([Cl:17])=[O:9])([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 65578Oxalyl chlorideHCID 5867093-Isopropoxybenzoic acid

Product 1

HCID 47694623-Isopropoxybenzoyl chloride

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Combine 3-isopropoxybenzoic acid (50 mmol) and dichloromethane (100 mL). Cool in an ice bath. Add in dropwise fashion, oxalyl chloride (55 mmol). Allow the reaction mixture to warm to ambient temperature. After 2 h, concentrate in vacuo to obtain a residue. Use the title compound without further purification.

Workup

  1. temperatureCool in an ice bath
  2. concentrationconcentrate in vacuo
  3. customto obtain a residue

Sources & evidence

ORD record
ord-999c781410f84a2a95772ca02c76faab
Source dataset
uspto-grants-1997_06
Patent number
US05635510

Reaction notes

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