3-Isopropoxybenzoyl chloride → 2-[3-(4-Trifluoromethyl-phenyl)-1-(3-isopropoxy-benzoyl)-pyrrolidin-3-yl]-ethanol

HRID 1683075Notes

Reaction equation

HRID 1683075 reaction equation
[F:1][C:2]([F:18])([F:17])[C:3]1[CH:8]=[CH:7][C:6]([C:9]2([CH2:14][CH2:15][OH:16])[CH2:13][CH2:12][NH:11][CH2:10]2)=[CH:5][CH:4]=1.[CH:19]([O:22][C:23]1[CH:24]=[C:25]([CH:29]=[CH:30][CH:31]=1)[C:26](Cl)=[O:27])([CH3:21])[CH3:20]>>[F:18][C:2]([F:17])([F:1])[C:3]1[CH:4]=[CH:5][C:6]([C:9]2([CH2:14][CH2:15][OH:16])[CH2:13][CH2:12][N:11]([C:26](=[O:27])[C:25]3[CH:29]=[CH:30][CH:31]=[C:23]([O:22][CH:19]([CH3:20])[CH3:21])[CH:24]=3)[CH2:10]2)=[CH:7][CH:8]=1

Participants

3

Reactant 2

HCID 47694623-Isopropoxybenzoyl chlorideHCID 183334872-[3-(4-Trifluoromethyl-phenyl)-pyrrolidin-3-yl]-ethanol

Product 1

HCID 545139052-[3-(4-Trifluoromethyl-phenyl)-1-(3-isopropoxy-benzoyl)-pyrrolidin-3-yl]-ethanol

Procedure

Prepare by the method of example 3.1 using 2-[3-(4-trifluoromethyl-phenyl)-pyrrolidin-3-yl]-ethanol (23 mmol) and 3-isopropoxy-benzoyl chloride (23 mmol). Chromatograph on silica gel to give the title compound.

Sources & evidence

ORD record
ord-265f07697c9047cd8cbbbfc6e5727e92
Source dataset
uspto-grants-1997_06
Patent number
US05635510

Reaction notes

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