Sulfuric Acid → 3-Tetrahydropyranyloxyethyl-3-(3,4-dichlorophenyl)pyrrolidine

HRID 1683085Notes

Reaction equation

HRID 1683085 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2([CH2:15][CH2:16][O:17][CH:18]3[CH2:23][CH2:22][CH2:21][CH2:20][O:19]3)[CH2:13][NH:12][C:11](=O)[CH2:10]2)[CH:5]=[CH:6][C:7]=1[Cl:8].OS(O)(=O)=O>>[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2([CH2:15][CH2:16][O:17][CH:18]3[CH2:23][CH2:22][CH2:21][CH2:20][O:19]3)[CH2:13][NH:12][CH2:11][CH2:10]2)[CH:5]=[CH:6][C:7]=1[Cl:8]

Participants

3

Reactant 2

HCID 1118Sulfuric AcidHCID 211976714-(2-Tetrahydropyranyloxyethyl)-4-(3,4-dichlorophenyl)-2-pyrrolidone

Product 1

HCID 211976873-Tetrahydropyranyloxyethyl-3-(3,4-dichlorophenyl)pyrrolidine

Procedure

Prepare according to the method of example 1.3.2 using 4-(3,4-dichloro-phenyl)-4-[2-(tetrahydro-pyran-2-yloxy)ethyl ]-pyrrolidin-2-one (as prepared in example 11.3) (3 mmol), LiA1H4 (18 mmol) H2SO4 (99.999%) (9 mmol). Purify to give the title compound.

Workup

  1. customPrepare
  2. customPurify

Sources & evidence

ORD record
ord-5880b5e7d2ff4bc9aac696a5251fb9fe
Source dataset
uspto-grants-1997_06
Patent number
US05635510

Reaction notes

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