反应详情

1.14 g (3.0 mmol) of benzhydryl (2S,3R,5R)-3-formyl-3-methyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylate were dissolved in 15 ml of 1,2-butylene oxide, treated with 1.38 g (3.6 mmol) of (1,2,4-oxadiazol-3-yl)methyl-triphenylphosphonium chloride and refluxed for 10 hours. Subsequently, the mixture was filtered, the filtrate is evaporated and the residual brown oil was chromatographed over silica gel (0.040-0.063 mm particle size) with methylene chloride as the eluent.

1. temperaturerefluxed for 10 hours
2. filtrationSubsequently, the mixture was filtered
3. customthe filtrate is evaporated
4. customthe residual brown oil was chromatographed over silica gel (0.040-0.063 mm particle size) with methylene chloride as the eluent