4-Methyl-5-(2-hydroxyethyl)thiazole → O-2-(4-Methylthiazol-5-yl)ethyl-6,7-dimethoxyisochroman-3-ol ether
Reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[O:13][CH3:14])[CH2:9][O:8][C:7](=[O:15])[CH2:6]2.[CH3:16][C:17]1[N:18]=[CH:19][S:20][C:21]=1[CH2:22][CH2:23]O.CC1N(CCCO)C2C=CN=CC=2N=1>>[CH3:16][C:17]1[N:18]=[CH:19][S:20][C:21]=1[CH2:22][CH2:23][O:15][CH:7]1[CH2:6][C:5]2[C:10](=[CH:11][C:12]([O:13][CH3:14])=[C:3]([O:2][CH3:1])[CH:4]=2)[CH2:9][O:8]1.[CH3:6][CH2:7][O:8][CH2:9][CH3:10]Participants
4
Procedure
O-2-(4-Methylthiazol-5-yl)ethyl-6,7-dimethoxyisochroman-3-ol ether was prepared by the procedure of Example 2 employing 6,7-dimethoxyisochroman-3-one in lieu of undecanoic-gamma-lactone and 2-(4-methylthiazol-5-yl)ethanol in lieu of 3-(2-methylimidazo[4,5-c]pyrid-1-yl)propanol.
Sources & evidence
- ORD record
- ord-835c871bb7ef46c4a9998fb993811e60
- Source dataset
- uspto-grants-1997_06
- Patent number
- US05637595
Reaction notes
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