HCID 19042891, compound → HCID 19042902, compound

HRID 1683284Notes

Reaction equation

HRID 1683284 reaction equation
[CH3:1][C:2]1[CH:22]=[CH:21][C:5]([O:6][C:7]2[CH:8]=[C:9]3[C:13](=[CH:14][CH:15]=2)[NH:12][C:11]([C:16]([O:18]CC)=[O:17])=[CH:10]3)=[CH:4][CH:3]=1>[OH-].[Na+]>[CH3:1][C:2]1[CH:22]=[CH:21][C:5]([O:6][C:7]2[CH:8]=[C:9]3[C:13](=[CH:14][CH:15]=2)[NH:12][C:11]([C:16]([OH:18])=[O:17])=[CH:10]3)=[CH:4][CH:3]=1

Participants

3

Reactant 1

HCID 19042891HCID 19042891, compound

Product 1

HCID 19042902HCID 19042902, compound

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Procedure

Ethyl 5-(4-methylphenoxy)indole-2-carboxylate (1.0 g, 3.39 mmol) was hydrolysed in methanolic NaOH (3.2M, 6.0 mL) at reflux, for 1 hr. After work-up the product: 5-(4-methylphenoxy)indole-2-carboxylic acid was obtained as an almost white solid, 0.92 g (ca 100%).

Workup

  1. temperatureat reflux, for 1 hr

Sources & evidence

ORD record
ord-92eecd3873ef4003997b0dcd826492b7
Source dataset
uspto-grants-1997_06
Patent number
US05637593

Reaction notes

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