反应详情

1.0 g of 3,4-dichlorophenyl 4'-bromomethyl-4-biphenylyl ketone, 1.5 ml of N-allylmethylamine and 0.84 g of potassium carbonate in 25 ml of ethanol are heated to boiling under reflux for 4 hours. The mixture is evaporated and the residue is extracted with ether. The extracts are dried over magnesium sulfate and treated with an ethereal hydrogen chloride solution. The precipitated hydrochloride is filtered and dried. 4'-[(Allylmethylamino)methyl]-4-biphenylyl 3,4-dichlorphenyl ketone hydrochloride, m.p. 160° C., is obtained.

1. temperatureunder reflux for 4 hours
2. customThe mixture is evaporated
3. extractionthe residue is extracted with ether
4. dry with materialThe extracts are dried over magnesium sulfate
5. additiontreated with an ethereal hydrogen chloride solution
6. filtrationThe precipitated hydrochloride is filtered
7. customdried