HCID 54400567, compound → HCID 19040307, compound

HRID 1683662Notes

Reaction equation

HRID 1683662 reaction equation
[N:1]1([CH2:7][CH2:8][CH2:9][P:10]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)(=[O:14])[O:11]CC)[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1>Cl>[N:1]1([CH2:7][CH2:8][CH2:9][P:10]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)(=[O:11])[OH:14])[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1

Participants

3

Reactant 1

HCID 54400567HCID 54400567, compound

Product 1

HCID 19040307HCID 19040307, compoundYield 115.1%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

A solution of ethyl [3-(morpholin-4-yl)propyl](phenyl)phosphinate (300 mg, 1.0 mmol) in 4N HCl (5 ml) was refluxed for 18 hours. Lyophilization afforded 310 mg (100%) of the title compound as an amorphous hygroscopic solid; MS: 270 m/z (M+H)+.

Sources & evidence

ORD record
ord-063310b4dea14805a6204a5ffd174eb2
Source dataset
uspto-grants-1997_06
Patent number
US05639732

Reaction notes

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