Potassium Carbonate → HCID 15335270, compound

HRID 1683673Notes

Reaction equation

HRID 1683673 reaction equation
[NH2:1][C:2]1[C:7]([C:8]#[N:9])=[N:6][C:5](Br)=[C:4]([CH3:11])[N:3]=1.[F:12][C:13]([F:28])([F:27])[C:14]1[CH:15]=[C:16](B(O)O)[CH:17]=[C:18]([C:20]([F:23])([F:22])[F:21])[CH:19]=1.C(=O)([O-])[O-].[K+].[K+]>C1(C)C=CC=CC=1>[NH2:1][C:2]1[C:7]([C:8]#[N:9])=[N:6][C:5]([C:16]2[CH:17]=[C:18]([C:20]([F:23])([F:21])[F:22])[CH:19]=[C:14]([C:13]([F:12])([F:28])[F:27])[CH:15]=2)=[C:4]([CH3:11])[N:3]=1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 1562653,5-Bis-trifluoromethylphenylboronic acidHCID 15335269HCID 15335269, compound

Product 1

HCID 15335270HCID 15335270, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

This compound is prepared in a manner analogous to that of Step A of Example 4, using 1.7 grams (0.008 mole) of 2-amino-3-cyano-5-bromo-6-methylpyrazine, 3.2 grams (0.012 mole) of 3,5-di(trifluoromethyl)phenylboronic acid, 4.3 grams (0.031 mole) of potassium carbonate and 0.3 gram of tetrakis(triphenylphosphine)palladium(0)in 150 mL of toluene, yielding 2-amino-3-cyano-5-[3,5-di(trifluoro-methyl)phenyl]-6-methylpyrazine.

Workup

  1. customThis compound is prepared in a manner analogous to that of Step A of Example 4

Sources & evidence

ORD record
ord-a30c82ce7c9d4448a9e1822ba9d28461
Source dataset
uspto-grants-1997_06
Patent number
US05639753

Reaction notes

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