Potassium Carbonate → 3-Amino-6-ethynylpicolinonitrile

HRID 1683683Notes

Reaction equation

HRID 1683683 reaction equation
[NH2:1][C:2]1[C:3]([C:14]#[N:15])=[N:4][C:5]([C:8]#[C:9][Si](C)(C)C)=[CH:6][CH:7]=1.C(=O)([O-])[O-].[K+].[K+]>CO>[NH2:1][C:2]1[C:3]([C:14]#[N:15])=[N:4][C:5]([C:8]#[CH:9])=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 190407873-Amino-2-cyano-6-(trimethylsilylethynyl)pyridine

Product 1

HCID 190407883-Amino-6-ethynylpicolinonitrile

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

This compound is prepared in a manner analogous to that of Step B of Example 9, using 1.3 grams (0.006 mole) of 3-amino-2-cyano-6-(trimethylsilylethynyl)pyridine and 0.9 gram (0.006 mole) of potassium carbonate in 50 mL of methanol, yielding 3-amino-2-cyano-6-ethynylpyridine. This reaction is repeated several times.

Workup

  1. customThis compound is prepared in a manner analogous to that of Step B of Example 9

Sources & evidence

ORD record
ord-658ef445c82d43ea83004b2da002fedc
Source dataset
uspto-grants-1997_06
Patent number
US05639753

Reaction notes

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