Ammonium Hydroxide → 2-{2-[(2-hydroxyethyl)amino]-1H-benzimidazol-1-yl}-1-phenylethanone

HRID 1683716Notes

Reaction equation

HRID 1683716 reaction equation
[OH-].[NH4+].Br.Br.[OH:5][CH2:6][CH2:7][NH:8][C:9]1[N:13]([CH2:14][C:15]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)=[O:16])[C:12]2[CH:23]=[CH:24][CH:25]=[CH:26][C:11]=2[N:10]=1>>[OH:5][CH2:6][CH2:7][NH:8][C:9]1[N:13]([CH2:14][C:15]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)=[O:16])[C:12]2[CH:23]=[CH:24][CH:25]=[CH:26][C:11]=2[N:10]=1

Participants

3

Reactant 2

HCID 14923Ammonium HydroxideHCID 190408002-(2-Hydroxyethylamino)-1-phenacylbenzimidazole dihydrobromide

Product 1

HCID 28501002-{2-[(2-hydroxyethyl)amino]-1H-benzimidazol-1-yl}-1-phenylethanone

Procedure

Add 22% ammonium hydroxide to 75 ml of a hot solution of the dihydrobromide obtained in Step A in 95° alcohol until a pH of approximately 10 is obtained. The title compound precipitates and is filtered, washed with water and dried.

Workup

  1. customis obtained
  2. customThe title compound precipitates
  3. filtrationis filtered
  4. washwashed with water
  5. customdried

Sources & evidence

ORD record
ord-39c6f81e51a241a8abc5726e9ea2658f
Source dataset
uspto-grants-1997_06
Patent number
US05639756

Reaction notes

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