反应详情

Add 0.35 g (9.3 mmol) of sodium borohydride in small portions, with vigorous stirring, to a suspension of 3.0 g (9.3 mmol) of 10-(4-chlorophenacyl)-2,3,4,10-tetrahydropyrimidino[1,2-a]benzimidazole (obtained in Example 50) in 20 ml of ethanol. Maintain stirring for one hour and leave for 12 hours at room temperature. Acidify with hydrochloric acid, and evaporate the reaction mixture. Treat the residue with ammonium hydroxide and extract with chloroform. The organic phase obtained is passed over a column of alumina. Evaporate the solvent. The residue is the title compound.

1. temperatureMaintain
2. customleave for 12 hours at room temperature
3. customevaporate the reaction mixture
4. additionTreat the residue with ammonium hydroxide
5. extractionextract with chloroform
6. customThe organic phase obtained
7. customEvaporate the solvent