Hydrochloric Acid → (R)-1-(2-(((2-Phenylcyclohex-2-enylidene)amino)oxy)ethyl)-3-piperidinecarboxylic acid hydrochloride

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Reaction Steps

The above ester (0.4 g, 1.1 mmol) was dissolved in ethanol (10 ml) and 4N sodium hydroxide (1 ml) was added. The mixture was stirred at ambient temperature for 3 h and excess concentrated hydrochloric acid was added followed by dichloromethane (400 ml). The suspension was dried (MgSO4) and the solvent evaporated in vacuo. The residue was re-evaporated with acetone, dissolved in acetone (10 ml) and left for crystallisation. This afforded 0.17 g of the title compound as a solid.

Provenance & Evidence