1h-1,2,4-Triazole sodium salt → HCID 19040657, compound

HRID 1683765Notes

Reaction equation

HRID 1683765 reaction equation
[Cl:1][C:2]1[C:7]2[CH2:8][CH2:9][N:10]([CH3:13])[CH2:11][CH2:12][C:6]=2[C:5]([O:14][CH:15](O)[CH3:16])=[CH:4][CH:3]=1.CC1C=CC(S([O-])(=O)=O)=CC=1.[Na].[NH:30]1[CH:34]=[N:33][CH:32]=[N:31]1>>[ClH:1].[Cl:1][C:2]1[C:7]2[CH2:8][CH2:9][N:10]([CH3:13])[CH2:11][CH2:12][C:6]=2[C:5]([O:14][CH2:15][CH2:16][N:30]2[CH:34]=[N:33][CH:32]=[N:31]2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 454898221h-1,2,4-Triazole sodium saltHCID 131720046HCID 131720046, compound

Product 1

HCID 19040657HCID 19040657, compound

Procedure

Following the general procedure of Example 2, [(9-chloro-2,3,4,5-tetrahydro-3-methyl-1H-3-benzazepin-6-yl) oxy]ethanol 4-methylbenzenesulfonate was heated with one equivalent of 1H-1,2,4-triazole sodium salt (prepared from 1H-1,2,4-triazole and sodium hydride in dimethylformamide) at 65° C. for 30 minutes to give 6-chloro-2,3,4,5-tetrahydro-3-methyl-9-[2-(1H-1,2,4-triazol-1-yl)ethoxy]-1H-3-benzazepine hydrochloride; mp 204°-211° C.

Sources & evidence

ORD record
ord-e7a395aac8064c23a35ce3ac11a1bfb1
Source dataset
uspto-grants-1997_06
Patent number
US05639748

Reaction notes

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