1h-1,2,4-Triazole sodium salt → HCID 19040657, compound

Participants

Reaction Steps

Following the general procedure of Example 2, [(9-chloro-2,3,4,5-tetrahydro-3-methyl-1H-3-benzazepin-6-yl) oxy]ethanol 4-methylbenzenesulfonate was heated with one equivalent of 1H-1,2,4-triazole sodium salt (prepared from 1H-1,2,4-triazole and sodium hydride in dimethylformamide) at 65° C. for 30 minutes to give 6-chloro-2,3,4,5-tetrahydro-3-methyl-9-[2-(1H-1,2,4-triazol-1-yl)ethoxy]-1H-3-benzazepine hydrochloride; mp 204°-211° C.

Provenance & Evidence