1H-Pyrazole, 4-chloro- → HCID 19040645, compound

HRID 1683773Notes

Reaction equation

HRID 1683773 reaction equation
[Cl:1][C:2]1[C:12]2[CH2:11][CH2:10][N:9]([CH3:13])[CH2:8][CH2:7][C:6]=2[C:5]([CH2:14][CH2:15][CH2:16]Cl)=[CH:4][CH:3]=1.[Na].N1C=NC=N1.[Cl:24][C:25]1[CH:26]=[N:27][NH:28][CH:29]=1>>[ClH:1].[Cl:1][C:2]1[C:12]2[CH2:11][CH2:10][N:9]([CH3:13])[CH2:8][CH2:7][C:6]=2[C:5]([CH2:14][CH2:15][CH2:16][N:27]2[CH:26]=[C:25]([Cl:24])[CH:29]=[N:28]2)=[CH:4][CH:3]=1

Participants

4

Reactant 3

HCID 275241H-Pyrazole, 4-chloro-HCID 19040619HCID 19040619, compoundHCID 454898221h-1,2,4-Triazole sodium salt

Product 1

HCID 19040645HCID 19040645, compoundYield 60%

Procedure

Using the general procedure of Example 11, replacing [(9-chloro-2,3,4,5-tetrahydro-3-methyl-1H-3-benzazepin-6-yl)oxy]ethanol 4-methylbenzenesulfonate with 6-chloro-9-(3-chloropropyl)-2,3,4,5-tetrahydro-3-methyl-1H-3-benzazepine and 1H-1,2,4-triazole sodium salt with 4-chloro-1H-pyrazole gave 0.33 g (60%) of 6-chloro-9-[3-(4-chloro-1H-pyrazol-1-yl)propyl]-2,3,4,5-tetrahydro-3-methyl-1H-3-benzazepine hydrochloride; mp 142.5°-145° C.

Sources & evidence

ORD record
ord-7eae72bf5df14b36a89312275130a350
Source dataset
uspto-grants-1997_06
Patent number
US05639748

Reaction notes

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