Bromine → HCID 18511696, compound

HRID 1683777Notes

Reaction equation

HRID 1683777 reaction equation
[Br:1]Br.[CH2:3]([O:5][C:6]([C:8]1[C:13]([O:14]C(=O)C)=[CH:12][CH:11]=[C:10]([C:18](=[O:20])[CH3:19])[N:9]=1)=[O:7])[CH3:4]>C(O)(=O)C>[BrH:1].[CH2:3]([O:5][C:6]([C:8]1[C:13]([OH:14])=[CH:12][CH:11]=[C:10]([C:18](=[O:20])[CH2:19][Br:1])[N:9]=1)=[O:7])[CH3:4]

Participants

4

Reactant 2

HCID 24408BromineHCID 15541469HCID 15541469, compound

Product 1

HCID 18511696HCID 18511696, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Conditions

Temperature
75 °C

Procedure

0.19 ml of bromine was dropwise added to a solution of 0.88 g of 2-ethoxycarbonyl-3-acetyloxy-6-acetylpyridine dissolved in 8.8 ml of acetic acid. The mixture was stirred at 75° C. for 5 minutes to obtain 0.77 g of 2-ethoxycarbonyl-3-hydroxy-6-(2-bromoacetyl)pyridine hydrobromide.

Sources & evidence

ORD record
ord-c16193f2917f481a83baa183af809a4c
Source dataset
uspto-grants-1997_06
Patent number
US05639770

Reaction notes

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