Phthalic Anhydride → HCID 16789391, compound

HRID 1683880Notes

Reaction equation

HRID 1683880 reaction equation
[C:1]1(=[O:11])[O:6][C:4](=O)[C:3]2=[CH:7][CH:8]=[CH:9][CH:10]=[C:2]12.[NH2:12][C:13]1[CH:18]=[CH:17][C:16]([CH2:19][C:20]([OH:22])=[O:21])=[CH:15][CH:14]=1>C(O)(=O)C>[O:11]=[C:1]1[C:2]2[C:3](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:4](=[O:6])[N:12]1[C:13]1[CH:14]=[CH:15][C:16]([CH2:19][C:20]([OH:22])=[O:21])=[CH:17][CH:18]=1

Participants

4

Reactant 2

HCID 6811Phthalic AnhydrideHCID 145334-Aminophenylacetic acid

Product 1

HCID 16789391HCID 16789391, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

Phthalic acid anhydride (15.1 g, 102 mmol) and 4-amino phenyl acetic acid (15.2 g, 102 mmol) were dissolved in acetic acid and heated at reflux for 1 hour. Upon cooling on an ice bath, the product crystallized. The solid was filtered off, washed with water, and dried under vacuum overnight. The yield of the title compound was 24.1 g (86%) as an off white solid.

Workup

  1. temperatureheated
  2. temperatureat reflux for 1 hour
  3. temperatureUpon cooling on an ice bath
  4. customthe product crystallized
  5. filtrationThe solid was filtered off
  6. washwashed with water
  7. customdried under vacuum overnight

Sources & evidence

ORD record
ord-fce27708133e44edb114726a1657e116
Source dataset
uspto-grants-1997_06
Patent number
US05639778

Reaction notes

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