Water → HCID 19041522, compound

HRID 1683893Notes

Reaction equation

HRID 1683893 reaction equation
[NH2:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]2[C:3]=1[CH2:4][CH:5]([N:11]([CH2:16][CH2:17][CH3:18])[C:12](=O)[CH2:13][CH3:14])[CH2:6]2.[H-].[Al+3].[Li+].[H-].[H-].[H-].O.[OH-].[Na+]>C(OCC)C>[CH2:16]([N:11]([CH2:12][CH2:13][CH3:14])[CH:5]1[CH2:4][C:3]2[C:2]([NH2:1])=[CH:10][CH:9]=[CH:8][C:7]=2[CH2:6]1)[CH2:17][CH3:18]

Participants

6

Reactant 4

HCID 962Water2×HCID 14798Sodium HydroxideHCID 19041506HCID 19041506, compoundHCID 21226445Aluminium lithium hydride

Product 1

HCID 19041522HCID 19041522, compoundYield 90.4%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent2×

Procedure

A solution of N-(4-amino-indan-2-yl)-N-propylpropionamide (0.5 g, 2.0 mmol) in dry diethyl ether (10 mL) was added to a slurry of lithium aluminum hydride (0.2 g, 5.4 mmol) in diethyl ether (50 mL) at ambient temperature. After stirring for 1.5 hours water (0.2 mL) followed by 15% sodium hydroxide (0.2 mL) and water (0.6 mL). After stirring for 10 minutes, the inorganic material was filtered off and the resulting solution was evaporated to yield 0.42 g (90%) of the desired product as an oil.:

Workup

  1. filtrationthe inorganic material was filtered off
  2. customthe resulting solution was evaporated

Sources & evidence

ORD record
ord-90dd2a3d2e644c37a04e1f35e0c6a4ab
Source dataset
uspto-grants-1997_06
Patent number
US05639778

Reaction notes

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