反应详情

温度

156 °C

5-Amino-3-(2-dimethylaminoethyl)indole and 2-fluoronitrobenzene were used. Pyridine was used as base, bromobenzene was used as solvent, and the reaction was heated at reflux (156° C.) for 11 hours. Chromatography afforded the title compound (82%) as a dark red solid: mp, 116.0°-117.0° C.; 13C NMR (CD3OD) δ146.7, 136.7, 133.2, 131.0, 129.5, 127.2, 124.7, 121.3, 117.3, 117.2, 117.0, 114.1,113.4, 61.4, 45.4, 24.2; HRMS calculated for C18H20N4O2 324.1588, found 324.1564. Anal. calcd. for C18H20N4O2 1/3H2O: C, 65.44; H, 6.31; N, 16.96. Found: 65.44; H, 5.92; N, 16.69.

1. temperaturethe reaction was heated