Ethanol → HCID 138962963, compound

HRID 1683941Notes

Reaction equation

HRID 1683941 reaction equation
[O-][CH2:2]C.[Na+].C(O)C.CI.[C:10]([NH:15][C:16]([NH2:18])=[S:17])([O:12][CH2:13][CH3:14])=[O:11]>CCOCC>[CH3:2][S:17][C:16](=[NH:18])[NH:15][C:10]([O:12][CH2:13][CH3:14])=[O:11]

Participants

6

Reactant 4

HCID 702EthanolHCID 6328Methyl iodideHCID 2723922Sodium ethoxideHCID 6451585Carbamic acid, (aminothioxomethyl)-, ethyl ester

Product 1

HCID 138962963HCID 138962963, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Conditions

Temperature
21 °C

Procedure

To a solution of sodium ethoxide in ethanol (made by addition of sodium (0.155 g, 6.7 mmol) to dry ethanol(15 ml)) was added methyl iodide (1.47 ml, 23.6 mmol) followed by N-carbethoxythiourea (1.0 g, 6.7 mmol). The resulting solution was stirred at 21° C. under nitrogen for 1 hr. This was then treated with ether (32 ml) and the resultant precipitate filtered off. The filtrate was evaporated to a clear syrup, which crystallised at 0-4° C. to give the title compound as a white solid (0.815 g).

Workup

  1. filtrationthe resultant precipitate filtered off
  2. customThe filtrate was evaporated to a clear syrup, which
  3. customcrystallised at 0-4° C.

Sources & evidence

ORD record
ord-0eb51fa9da2b4042ba507f479c3d4131
Source dataset
uspto-grants-1997_06
Patent number
US05639786

Reaction notes

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