Diisobutylaluminum hydride → 2-[1-(1-(4-Bromobenzyl)-5-methoxy-2-methyl-1H-indol-3-yl) cyclopropyl]ethanol

Participants

Reaction Conditions

Reaction Steps

To a -78° C. solution of ester from Step 7 (442 mg, 1 mmol) in 5 mL THF was added DIBAH (1.5M in toluene, 2 mL, 3 mmol), and the mixture was stirred for 2 hours with slow warming to 0° C. The reaction mixture was partitioned between 1N HCl and ethyl acetate. The organic layer was washed with brine, dried over MgSO4 and evaporated. The residue was filtered through a plug of silica gel to give 319 mg of the title compound which was used without further purification.

Provenance & Evidence