反应详情

温度

0 °C

To a -78° C. solution of ester from Step 7 (442 mg, 1 mmol) in 5 mL THF was added DIBAH (1.5M in toluene, 2 mL, 3 mmol), and the mixture was stirred for 2 hours with slow warming to 0° C. The reaction mixture was partitioned between 1N HCl and ethyl acetate. The organic layer was washed with brine, dried over MgSO4 and evaporated. The residue was filtered through a plug of silica gel to give 319 mg of the title compound which was used without further purification.

1. customThe reaction mixture was partitioned between 1N HCl and ethyl acetate
2. washThe organic layer was washed with brine
3. dry with materialdried over MgSO4
4. customevaporated
5. filtrationThe residue was filtered through a plug of silica gel