反应详情

To the ethyl ester from Example 7, Step 1 (2.00 g, 8.10 mmol) dissolved in THF (40.0 mL) was added at -78° C. a 0.5M solution of KHMDS (16.0 mL, 8.10 mmol) in toluene and HMPA (200 μL). After a period of 10 min, 4-bromobenzyl bromide was added to the resulting mixture. The reaction mixture was brought to room temperature, quenched by the addition of 25% aqueous NH4OAc solution, extracted with EtOAc, dried over Na2SO4 and evaporated in vacuo. The title product was purified by flash chromotography (15% to 20% EtOAc in hexane) (1.5 g).

1. customwas brought to room temperature
2. customquenched by the addition of 25% aqueous NH4OAc solution
3. extractionextracted with EtOAc
4. dry with materialdried over Na2SO4
5. customevaporated in vacuo
6. customThe title product was purified by flash chromotography (15% to 20% EtOAc in hexane) (1.5 g)