HuagongsheHuagongshe Chemistry Print Report · For research reference only
Lawesson's reagent → 4-[1-(4-Bromobenzyl)-5-methoxy-2-methyl-1H-indol-3-yl]-3-methylbutanethioamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Lawesson's reagent | HCID 87949 | — |
| Reactant | 4-[1-(4-Bromobenzyl)-5-methoxy-2-methyl-1H-indol-3-yl]-3-methylbutanamide | HCID 19041650 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 4-[1-(4-Bromobenzyl)-5-methoxy-2-methyl-1H-indol-3-yl]-3-methylbutanethioamide | HCID 19041725 | — |
Reaction Steps
To the amide (530 mg, 1.30 mmol) of Example 90 in 1,4-dioxane (10.0 mL) was added the Lawesson reagent (310 mg, 0.767 mmol). After refluxing for 2 min, the solvent was evaporated in vacuo and the title product was purified by flash chromatography (30% EtOAc in hexane).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05639780 |
| Source dataset | uspto-grants-1997_06 |
| ORD ID | ord-91a6c27577af4eaba46538f7760c50aa |
| Source note | uspto-grants-1997_06 |