反应详情

温度

150 °C

The method used to prepare the phenol is basically the procedure reported by Claudi et. al. [med. Chem. 33, 2408-2412 (1990) with modification according to Lambooy [J. Amer. Chem. Soc. 72, 5327-5328 (1950)]. In a three-necked round-bottom flask (1000 mL), equipped with dropping-funnel and a magnetic stirrer, 2-fluoro-methoxyaniline (11.3 g, 80 mmol ), concentrated sulfuric acid (35 mL) and water (200 mL) were mixed and then cooled to 3°-5° C. A solution of sodium nitrite (6.07 g; 88 mmol) in water (20 mL) was added dropwise to the stirred mixture above at 2°-4° C. When the addition was completed the solution was stirred for five minutes and then urea (0.48 g) was added followed by water (100 mL). Meanwhile an apparatus was prepared consisting of a three-necked round-bottom flask (1000 mL), a thermometer, an electrical heating mantle, a steam distillation apparatus, and long (40 cm) water-jacketed condensor on top of which a 500 mL dropping funnel was attached. In the flask CuSO4 ×5H2O (56 g), concentrated sulfuric acid (160 mL) and water (160 mL) were placed. The mixture was heated to 150° C., the diazonium salt solution, cooled all the time by adding small chunks of the ice to it, was added dropwise from the dropping funnel, and a current of steam was passed through the system to remove the phenol. The distillate was extracted with ether (3×400 mL) and the combined ether extracts were dried (MgSO4), filtered and concentrated in vacuo. The crude phenol was purified on a silica column eluted with ether/n-hexane (15:85) to afford 4.03 g of the title compound as a crystalline solid. Mp. 25°-26° C.

1. customIn a three-necked round-bottom flask (1000 mL), equipped with dropping-funnel and a magnetic stirrer
2. temperaturecooled to 3°-5° C
3. additionWhen the addition
4. customMeanwhile an apparatus was prepared
5. customconsisting of a three-necked round-bottom flask
6. distillation(1000 mL), a thermometer, an electrical heating mantle, a steam distillation apparatus, and long (40 cm) water-jacketed condensor on top of which a 500 mL
7. temperaturethe diazonium salt solution, cooled all the time
8. additionby adding small chunks of the ice to it
9. additionwas added dropwise from the dropping funnel
10. customto remove the phenol
11. extractionThe distillate was extracted with ether (3×400 mL)
12. dry with materialthe combined ether extracts were dried (MgSO4)
13. filtrationfiltered
14. concentrationconcentrated in vacuo
15. customThe crude phenol was purified on a silica column
16. washeluted with ether/n-hexane (15:85)