HRID1684395

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID313

Hydrochloric Acid

ClH

HCID3283

Diethyl Ether

C4H10O

2 次

结构：COc1ccc(C(C#N)(CCCCCN2Cc3cc(OC)c(OCCn4ccnc4)cc3C2)Sc2ccc(C)cc2)cc1OC

HCID10699180

未命名化合物

PRODUCTS

生成物

结构：COc1ccc(C(C#N)(CCCCCN2Cc3cc(OC)c(OCCn4ccnc4)cc3C2)Sc2ccc(C)cc2)cc1OC.Cl.Cl

HCID19042097

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID702

Ethanol

C2H6O

溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

To a solution of 0.196 g of α-(3,4-dimethoxyphenyl)-1,3-dihydro-5-[2-(1H-imidazol-1-yl)ethoxy]-6-methoxy-α-[(4-methylphenyl)thio]-2H-isoindole-2-heptanenitrile in 0.5 mL of methylene chloride is added 5 mL of diethyl ether and then 0.17 mL of 4.5N hydrochloric acid in ethyl alcohol. An additional 15 mL of diethyl ether is added and the solution stirred vigorously for 1 hour. The white solid is collected by filtration, washed with diethyl ether and dried. This affords 0.166 g of the desired product as a white solid.

WORKUP

后处理

filtrationThe white solid is collected by filtration
washwashed with diethyl ether
customdried

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-47ad6f5c4df44063aab202b3dc83cfdc
来源数据集: uspto-grants-1997_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05639887
来源说明: uspto-grants-1997_06

反应 SMILES

[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:11]([S:38][C:39]2[CH:44]=[CH:43][C:42]([CH3:45])=[CH:41][CH:40]=2)([CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][N:19]2[CH2:27][C:26]3[C:21](=[CH:22][C:23]([O:36][CH3:37])=[C:24]([O:28][CH2:29][CH2:30][N:31]4[CH:35]=[CH:34][N:33]=[CH:32]4)[CH:25]=3)[CH2:20]2)[C:12]#[N:13])[CH:6]=[CH:7][C:8]=1[O:9][CH3:10].C(OCC)C.[ClH:51]>C(Cl)Cl.C(O)C>[ClH:51].[ClH:51].[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:11]([S:38][C:39]2[CH:40]=[CH:41][C:42]([CH3:45])=[CH:43][CH:44]=2)([CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][N:19]2[CH2:27][C:26]3[C:21](=[CH:22][C:23]([O:36][CH3:37])=[C:24]([O:28][CH2:29][CH2:30][N:31]4[CH:35]=[CH:34][N:33]=[CH:32]4)[CH:25]=3)[CH2:20]2)[C:12]#[N:13])[CH:6]=[CH:7][C:8]=1[O:9][CH3:10]