反应详情

Subsequently, 13.2g (0.032 mol) of N-(4'-iodo-4-biphenyl)acetanilide thus obtained, 6.60 g (0.039 mol) of diphenylamine, 5.53 g (0.040 mol) of anhydrous potassium carbonate, 0.45 g (0.007 mol) of copper powder, and 10 ml of nitrobenzene were mixed. The reaction mixture was then allowed to undergo reaction at a temperature of 200° to 212° C. for 15 hours. The reaction product was then extracted with 100 ml of toluene. The insoluble contents were then removed by filtration. The filtrate was then concentrated to obtain an oily matter. The oily matter thus obtained was then dissolved in 60 ml of isoamyl alcohol. The material was then hydrolyzed with 1 ml of water and 2.64 g (0.040 mol) of 85% potassium hydroxide at a temperature of 130° C. The reaction solution was then subjected to steam distillation to distill off isoamyl alcohol. The residue was extracted with 250 ml of toluene, washed with water, and then concentrated to dryness. The concentrate was then purified by column chromatography (carrier: silica gel; elute: 1/2 mixture of toluene and n-hexane) to obtain 10.5 g (yield: 72.2%) of N,N,N'-triphenylbenzidine. The melting point of the product was from 167.5° C. to 168.5° C.

1. customreaction at a temperature of 200° to 212° C. for 15 hours
2. extractionThe reaction product was then extracted with 100 ml of toluene
3. customThe insoluble contents were then removed by filtration
4. concentrationThe filtrate was then concentrated
5. customto obtain an oily matter
6. customThe oily matter thus obtained
7. customat a temperature of 130° C
8. distillationThe reaction solution was then subjected to steam distillation
9. distillationto distill off isoamyl alcohol
10. extractionThe residue was extracted with 250 ml of toluene
11. washwashed with water
12. concentrationconcentrated to dryness
13. customThe concentrate was then purified by column chromatography (carrier: silica gel; elute: 1/2 mixture of toluene and n-hexane)