HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzoyl chloride → HCID 67715854, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzoyl chloride | HCID 7412 | — |
| Reactant | 5,11-dihydro-11-[[4-[3-(ethylamino)propyl]-1-piperidinyl]acetyl]-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one | HCID 19039412 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 67715854 | HCID 67715854 | 62% |
Reaction Steps
Prepared analogously to Example 1 from 5,11-dihydro-11-[[4-[3-(ethylamino)propyl]-1-piperidinyl]acetyl]-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one and benzoic acid chloride. The free base is dissolved in ethyl acetate and the dihydrochloride is precipitated by the addition of ethereal hydrochloric acid. The desired compound is obtained in a yield of 62% by recrystallisation from ethanol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05641772 |
| Source dataset | uspto-grants-1997_06 |
| ORD ID | ord-e0c1dad29b114944976a5a7eec96240f |
| Source note | uspto-grants-1997_06 |