Benzoyl chloride → HCID 67715854, compound

HRID 1684509Notes

Reaction equation

HRID 1684509 reaction equation
[CH2:1]([NH:3][CH2:4][CH2:5][CH2:6][CH:7]1[CH2:12][CH2:11][N:10]([CH2:13][C:14]([N:16]2[C:22]3[CH:23]=[CH:24][CH:25]=[CH:26][C:21]=3[C:20](=[O:27])[NH:19][C:18]3[CH:28]=[CH:29][CH:30]=[N:31][C:17]2=3)=[O:15])[CH2:9][CH2:8]1)[CH3:2].[C:32]([Cl:40])(=[O:39])[C:33]1[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=1>C(OCC)(=O)C>[ClH:40].[ClH:40].[C:32]([CH2:2][CH2:1][NH:3][CH2:4][CH2:5][CH2:6][CH:7]1[CH2:12][CH2:11][N:10]([CH2:13][C:14]([N:16]2[C:22]3[CH:23]=[CH:24][CH:25]=[CH:26][C:21]=3[C:20](=[O:27])[NH:19][C:18]3[CH:28]=[CH:29][CH:30]=[N:31][C:17]2=3)=[O:15])[CH2:9][CH2:8]1)(=[O:39])[C:33]1[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=1

Participants

4

Reactant 2

HCID 7412Benzoyl chlorideHCID 190394125,11-dihydro-11-[[4-[3-(ethylamino)propyl]-1-piperidinyl]acetyl]-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one

Product 1

HCID 67715854HCID 67715854, compoundYield 62%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

Prepared analogously to Example 1 from 5,11-dihydro-11-[[4-[3-(ethylamino)propyl]-1-piperidinyl]acetyl]-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one and benzoic acid chloride. The free base is dissolved in ethyl acetate and the dihydrochloride is precipitated by the addition of ethereal hydrochloric acid. The desired compound is obtained in a yield of 62% by recrystallisation from ethanol.

Workup

  1. customthe dihydrochloride is precipitated by the addition of ethereal hydrochloric acid

Sources & evidence

ORD record
ord-e0c1dad29b114944976a5a7eec96240f
Source dataset
uspto-grants-1997_06
Patent number
US05641772

Reaction notes

Loading…