HRID1684509

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID7412

Benzoyl chloride

C7H5ClO

结构：CCNCCCC1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1

HCID19039412

未命名化合物

PRODUCTS

生成物

结构：Cl.Cl.O=C(CCNCCCC1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1)c1ccccc1

HCID67715854

未命名化合物

收率 62%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID8857

Ethyl acetate

C4H8O2

PROCEDURE

实验过程

Prepared analogously to Example 1 from 5,11-dihydro-11-[[4-[3-(ethylamino)propyl]-1-piperidinyl]acetyl]-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one and benzoic acid chloride. The free base is dissolved in ethyl acetate and the dihydrochloride is precipitated by the addition of ethereal hydrochloric acid. The desired compound is obtained in a yield of 62% by recrystallisation from ethanol.

WORKUP

后处理

customthe dihydrochloride is precipitated by the addition of ethereal hydrochloric acid

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-e0c1dad29b114944976a5a7eec96240f
来源数据集: uspto-grants-1997_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05641772
来源说明: uspto-grants-1997_06

反应 SMILES

[CH2:1]([NH:3][CH2:4][CH2:5][CH2:6][CH:7]1[CH2:12][CH2:11][N:10]([CH2:13][C:14]([N:16]2[C:22]3[CH:23]=[CH:24][CH:25]=[CH:26][C:21]=3[C:20](=[O:27])[NH:19][C:18]3[CH:28]=[CH:29][CH:30]=[N:31][C:17]2=3)=[O:15])[CH2:9][CH2:8]1)[CH3:2].[C:32]([Cl:40])(=[O:39])[C:33]1[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=1>C(OCC)(=O)C>[ClH:40].[ClH:40].[C:32]([CH2:2][CH2:1][NH:3][CH2:4][CH2:5][CH2:6][CH:7]1[CH2:12][CH2:11][N:10]([CH2:13][C:14]([N:16]2[C:22]3[CH:23]=[CH:24][CH:25]=[CH:26][C:21]=3[C:20](=[O:27])[NH:19][C:18]3[CH:28]=[CH:29][CH:30]=[N:31][C:17]2=3)=[O:15])[CH2:9][CH2:8]1)(=[O:39])[C:33]1[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=1